Lymphocytic encephalitis: Difference between revisions

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:''For other uses of the concept of viruses in ''Battlestar Galactica'', see [[Virus]].''
{{disline|For other uses of the concept of viruses in ''Battlestar Galactica'', see [[Virus]].}}
[[image:LCMV.jpg|thumb|170px|right|An actual LCMV specimen, as observed under a light microscope]]
'''Lymphocytic encephalitis''' is a viral infectious disease caused by the Lymphocytic Choriomeningitis Virus (LCMV). Originally carried by rodents, primarily [[Life Forms of the Twelve Colonies#Mammals|rats]], LCMV is no longer lethal to humans, who have developed an immunity to the virus several hundred years ago.


'''Lymphocytic encephalitis''' is a viral disease that is highly lethal to [[Cylons (RDM)|Cylons]]. It is an ancient human disease that originally was carried by [[Life Forms of the Twelve Colonies|rodents]], primarily [[Life Forms of the Twelve Colonies|rats]]. A couple hundred years ago, humans developed an immunity to the virus. A beacon, believed to have been left by the Thirteenth Tribe on their way to [[Earth]], was contaminated by the virus. A Cylon Baseship discovered the beacon, and agents, upon examining it, unknowingly unleashed the virus infecting all of the Cylons aboard.
A [[Lion's Head beacon|beacon]], believed to have been left by the [[Thirteenth Tribe (RDM)|Thirteenth Tribe]] on their way to [[Earth (RDM)|Earth]], was contaminated by LCMV. When a basestar discovers the beacon while exploring the [[Lion's Head Nebula]], the [[Cylons (RDM)|Cylons]] bring the device on board and unleash the virus. Some time later, a team of Colonial marines discovers the drifting basestar and boards the vessel, finding everything save for a small group of humanoids dead. They take the ill Cylons (a [[Number Two|Two]], a [[Number Four|Four]], a [[Number Five|Five]], a [[Number Six|Six]], and an [[Number Eight|Eight]]) prisoner and return to ''Galactica'' just as the basestar's self-destruct mechanism activates and destroys the ship.


The virus is especially virulent in Cylons because there is a bio-electric feedback component to the pathogen. It corrupts how the brain of a [[Humanoid Cylon]] manages their immune system. If a Cylon who is infected dies and is [[Resurrection (RDM)|resurrected]], the disease will follow, infecting the [[Resurrection Ship]] and eventually the entire Cylon fleet.  
Though humans are immune, the virus is highly lethal to Cylons because of a bio-electric component that causes a fatal system error within the host. It is theorized that this system error disrupts the management of a humanoid Cylon's immune system, progressively weakening and eventually killing the infected individual. Furthermore, the Cylons speculate that if an infected host is [[Resurrection (RDM)|resurrected]], the system error will follow, potentially afflicting the [[Resurrection Ship]] and eventually the entire Cylon fleet.


This fact formed the basis of a plan devised by [[Lee Adama]] to eradicate the Cylon Race. The plan proposed that by killing Cylon prisoners infected with the virus within the vicinity of a resurrection ship, the aforementioned bio-electrical feedback effect would be spread to all Cylons upon download of the infected Cylons consciousnesses. The plan was ultimately thwarted by [[Helo]], who felt that the genocide of his wife's race, despite the fact that they were Cylons and had tried to do the same, was morally wrong. However, the plan was ill-conceived as there was nothing to stop the Cylons from destroying the Resurrection ship the moment they realised it was infected. The plan seemed to hinge on the idea that once in the Resurrection Ship the disease would somehow spread throughout the Cylon fleet and perhaps even the whole of Cylon-inhabited space, an assumption which was likely based on the dread with which the Cylons viewed the disease. Also, there was a strong possibility that a cure or treatment would have been found reasonably quickly, given the fact that [[Gaius Baltar|Baltar]] was immune to the virus and therefore must have been carrying relevant antibodies.
This theory forms the basis of a plan devised by [[Lee Adama]] to eradicate the Cylon race. By killing the infected Cylons prisoners near a Resurrection Ship, the aforementioned bio-electrical effect would be spread to all Cylons upon download. Ultimately, the plan is thwarted when [[Karl Agathon]] kills the prisoners before ''Galactica'' can penetrate the Resurrection Ship's upload radius. Agathon does this despite the risk of being executed for treason, as he feels that the genocide of the Cylon race, despite the fact that they had tried to do the same to mankind, is morally wrong.  
During the time that the infected Cylons are held captive aboard ''Galactica'', [[Cottle|Dr. Cottle]] creates a simple vaccine that dramatically reverses the effect of the virus on said Cylons. However, an antibody in their blood breaks down the vaccine's RNA backbone, rendering the treatment useless. Because of that, the Cylons require regular close interval injections of the vaccine, or their condition significantly worsens. If regular injections are provided, an infected Cylon could be kept alive indefinitely.


[[Cottle|Dr. Cottle]] believes he can create a simple vaccine that can dramatically reverse to effect on the Cylons. However, they have an antibody in their blood which breaks down the RNA of the vaccine. Because of that, they will need regular close interval injections of the vaccine or they will die. If regular injections are provided, an infected Cylon can be kept alive indefinitely.
Unlike the other Cylons [[Sharon Agathon]] displays immunity to the virus—although she is exposed to LCMV, the pathogen does not adversely affect her. Cottle postulates that human antibodies were transferred over to Sharon during her pregnancy with her half-human daughter [[Hera Agathon|Hera]], and that these antibodies are subduing the virus {{TRS|Torn}}.  


The strain of the virus that infected a [[baseship]] via the [[Lion's Head beacon]] is an exact match to one reported over 3,600 years ago, right around the time that the [[Thirteenth Colony]] left [[Kobol (RDM)|Kobol]] ([[A Measure of Salvation]]), as the Scrolls of [[Pythia]] imply.
== Notes ==
*[http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/lcmv/qa.htm Lymphocytic choriomeningitis] (of which encephalitis is one form) is an actual disease. As in the episode, the illness was spread through rodents on the real-world Earth. The effects on the Cylons appear similar to the symptoms in this CDC document.
*Arguably, the plan to kill all Cylons by exposing the Resurrection ship to the disease is ill-conceived; there is nothing to stop the Cylons from destroying the vessel after it is infected. Additionally, the plan seems to hinge on the idea that once in the Resurrection Ship the disease would spread throughout the Cylon fleet and perhaps even the whole of Cylon-inhabited space.


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Revision as of 16:38, 19 June 2021

An actual LCMV specimen, as observed under a light microscope

Lymphocytic encephalitis is a viral infectious disease caused by the Lymphocytic Choriomeningitis Virus (LCMV). Originally carried by rodents, primarily rats, LCMV is no longer lethal to humans, who have developed an immunity to the virus several hundred years ago.

A beacon, believed to have been left by the Thirteenth Tribe on their way to Earth, was contaminated by LCMV. When a basestar discovers the beacon while exploring the Lion's Head Nebula, the Cylons bring the device on board and unleash the virus. Some time later, a team of Colonial marines discovers the drifting basestar and boards the vessel, finding everything save for a small group of humanoids dead. They take the ill Cylons (a Two, a Four, a Five, a Six, and an Eight) prisoner and return to Galactica just as the basestar's self-destruct mechanism activates and destroys the ship.

Though humans are immune, the virus is highly lethal to Cylons because of a bio-electric component that causes a fatal system error within the host. It is theorized that this system error disrupts the management of a humanoid Cylon's immune system, progressively weakening and eventually killing the infected individual. Furthermore, the Cylons speculate that if an infected host is resurrected, the system error will follow, potentially afflicting the Resurrection Ship and eventually the entire Cylon fleet.

This theory forms the basis of a plan devised by Lee Adama to eradicate the Cylon race. By killing the infected Cylons prisoners near a Resurrection Ship, the aforementioned bio-electrical effect would be spread to all Cylons upon download. Ultimately, the plan is thwarted when Karl Agathon kills the prisoners before Galactica can penetrate the Resurrection Ship's upload radius. Agathon does this despite the risk of being executed for treason, as he feels that the genocide of the Cylon race, despite the fact that they had tried to do the same to mankind, is morally wrong.

During the time that the infected Cylons are held captive aboard Galactica, Dr. Cottle creates a simple vaccine that dramatically reverses the effect of the virus on said Cylons. However, an antibody in their blood breaks down the vaccine's RNA backbone, rendering the treatment useless. Because of that, the Cylons require regular close interval injections of the vaccine, or their condition significantly worsens. If regular injections are provided, an infected Cylon could be kept alive indefinitely.

Unlike the other Cylons Sharon Agathon displays immunity to the virus—although she is exposed to LCMV, the pathogen does not adversely affect her. Cottle postulates that human antibodies were transferred over to Sharon during her pregnancy with her half-human daughter Hera, and that these antibodies are subduing the virus (TRS: "Torn").

Notes

  • Lymphocytic choriomeningitis (of which encephalitis is one form) is an actual disease. As in the episode, the illness was spread through rodents on the real-world Earth. The effects on the Cylons appear similar to the symptoms in this CDC document.
  • Arguably, the plan to kill all Cylons by exposing the Resurrection ship to the disease is ill-conceived; there is nothing to stop the Cylons from destroying the vessel after it is infected. Additionally, the plan seems to hinge on the idea that once in the Resurrection Ship the disease would spread throughout the Cylon fleet and perhaps even the whole of Cylon-inhabited space.