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Hoyt's five-decade career includes notable films such as the groundbreaking science-fiction motion picture When Worlds Collide, Spartacus, and The Conqueror. The latter film, co-starring popular American actors John Wayne, Agnes Moorehead (Bewitched) and Susan Hayward, was filmed in an area contaminated with nuclear fallout from a ground-level test site. A very disproportionate percentage of the cast and crew of this movie eventually died of some form of cancer.
Hoyt's television career spanned almost every imaginable genre, from medical drama, science fiction, western, court drama, comedy, and spy dramas. Hoyt played Dr. Piper in the series pilot for the original Star Trek series, and had many recurring and brief roles in classic and contemporary TV shows, including The Virginian, Perry Mason, Hogan's Heroes, Get Smart, The Outer Limits, Gimme a Break!, Voyage to the Bottom of the Sea, The Time Tunnel and The Flying Nun. Perhaps Hoyt's most unusual credit is in the X-rated parody of Flash Gordon, called Flesh Gordon, in 1974.
Hoyt died of lung cancer in 1991.