|Fate:||Destroyed in the Battle of the Ionian Nebula|
The ship is lost in the Battle of the Ionian Nebula when a spiraling Cylon Raider, damaged by Viper fire, impacts near the engines, resulting in catastrophic damage. The resulting explosion destroys the ship with 600 people aboard (TRS: "He That Believeth In Me").
- The ship can first be seen joining Laura Roslin's convoy in the Miniseries. However, the name Pyxis is first introduced on the voting tally board in "Lay Down Your Burdens, Part II," and the ship is not identified as such until "He That Believeth In Me."
- It appears to be of very similar design to the ill-fated Olympic Carrier, and could possibly be another ship of the same class.
- The interior of Pyxis is shown in "The Plan" and in two deleted scenes from the two-part series finale. The inside of this ship has orange walls with seats identical to those inside Colonial One, with one set of top-facing windows and one set facing the side, also similar to Colonial One. However, the exterior of the ship features only one set of windows, creating a design goof, likely created through the redressing and reuse of Colonial One's interior sets.
- Pyxis is a minor southern constellation introduced by Nicolas Louis de Lacaille under the name Pyxis Nautica. It is perhaps supposed to represent the compass of Argo Navis.